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Biofluid Mechanics in Thrombosis and Hemostasis

Zixiang Leonardo Liu, Brown University

George Em Karniadakis, Brown University

David Bark, Washington University School of Medicine St. Louis

David N. Ku, Georgia Institute of Technology

This symposium will focus on the computational and experimental characterization of blood clot formation in thrombosis and hemostasis.  Clotting is a complex reactive flow problem that involves the interaction and reaction of various molecular and cellular-level participants that can form a sticky poroelastic tissue. This process can either impede the blood flow in arteries causing heart attacks and strokes or help stop bleeding during hemorrhagic injury, thus extremely critical for human health.  Understanding the flow-driven mechanisms of clotting is essential for the development of efficacious therapeutics and devices for preventing and treating thrombotic and hemostatic diseases.  The overarching goal of this symposium is to bring together researchers from both the computational and experimental sides to present recent progress and foster new ideas and collaborations in this area.

Topics of particular interest include but are not limited to the following:

-Multiscale or data-driven computational models for thrombus formation and embolism

-Microfluidic models for thrombus formation and bleeding

-Patient-specific modeling and its application in clinical intervention

-Margination, adhesion, and aggregation of platelets in blood flows

-Biotransport of von Willebrand factor and its implication in thrombosis

-Flow-mediated binding kinetics in thrombosis and hemostasis

-Thrombolysis under fluid disturbances

-Hemodynamics and clotting in blood-contacting devices (ECMO, VAD, etc.)